Monnapa TonanontPeerapong InthasornDittakan BoriboonhirunsarnWeerasak WongthirapornIssaracha SuphanitMahidol University2018-06-212018-06-212005-10-01Journal of the Medical Association of Thailand. Vol.88, No.10 (2005), 1349-135401252208012522082-s2.0-30844473763https://repository.li.mahidol.ac.th/handle/20.500.14594/16793Objectives: To evaluate the response and toxicity of methotrexate and folinic acid given as primary treatment of low and intermediate risk gestational trophoblastic disease (GTD). Material and Method: Medical records review was performed in patients who received methotrexate and folinic acid as a primary treatment of low and intermediate risk persistent GTD between January 1992 and December 2001. Response was defined as decline of beta human chorionic gonadotropin (hCG) to ≤ 5 mIU/ml (remission) after methotrexate and folinic acid treatment. Response rate was estimated and factors associated with response were evaluated. Results: Ninety four eligible patients were treated with intramuscular methotrexate and folinic acid. Complete remission was achieved in 64 cases (68%, 95%CI 58-78%). Mucositis (6.4%) and hepatotoxicity (6.4%) were the most common toxicity of methotrexate in the present study and none of these toxic effects was life threatening. Factors associated with response were initial serum hCG ≤ 10,000 mIU/ml and stage I disease. Conclusion: Methotrexate with folinic acid is effective treatment for low and intermediate risk GTD with minimal severe toxicity.Mahidol UniversityMedicineReviewSCOPUS