Anongruk Chim-OngCharin ThawornkunoPorntip Chavalitshewinkoon-PetmitrPhaibul PunyaritSongsak PetmitrMahidol UniversityArmy Institute of Pathology2018-11-092018-11-092014-01-01Asian Pacific Journal of Cancer Prevention. Vol.15, No.15 (2014), 6065-6070151373682-s2.0-84906271223https://repository.li.mahidol.ac.th/handle/20.500.14594/33377Background: Breast cancer is the most common malignancy in women worldwide, including Thailand, and is a major cause of mortality and morbidity, despite advances in diagnosis and treatment. Novel gene expression in breast cancer is a focus in searches for prognostic biomarkers and new therapeutic targets. Materials and Methods: The mRNA expression of novel B4GALT4, SLC35B2, and WDHD1 genes in breast cancer were examined in invasive ductal breast carcinoma (IDC) patients using quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR). Results: Among these genes, increased expression of SLC35B2 mRNA was significantly associated with TNM stage III + IV of IDC (p < 0.001). Hence, up-regulation of SLC35B2 may serve as a prognostic biomarker for poor prognosis, and is also a potential therapeutic target in breast cancer.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.7314/APJCP.2014.15.15.6065