Sattha RiyapanJeffrey LubinPenn State Health Milton S. Hershey Medical CenterMahidol University2018-12-112019-03-142018-12-112019-03-142016-11-01Air Medical Journal. Vol.35, No.6 (2016), 365-368153264971067991X2-s2.0-84994501928https://repository.li.mahidol.ac.th/handle/20.500.14594/41033© 2016 Air Medical Journal Associates Objective This study sought to determine the effectiveness of apneic oxygenation in preventing hypoxemia during prehospital rapid sequence intubation (RSI). Methods We performed a case-cohort study using a pre-existing database looking at intubation management by a single helicopter emergency medical service between July 2013 and June 2015. Apneic oxygenation using high-flow nasal cannula (15 L/min) was introduced to the standard RSI protocol in July 2014. Severe hypoxemia was defined as an incidence of oxygen saturation less than 90%. We compared patients who received apneic oxygenation during RSI with patients who did not using the Fisher exact test. Results Ninety-three patients were identified from the database; 29 (31.2%) received apneic oxygenation. Nineteen patients had an incidence of severe hypoxemia during RSI (20.43%; 95% confidence interval, 12.77%-30.05%). There was no statistically significant difference between the rate of severe hypoxemia between patients in the apneic oxygenation group versus the control group (17.2% vs. 21.9%, P =.78). Conclusion In this study, patients who received apneic oxygenation did not show a statistically significant difference in severe hypoxemia during RSI.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.amj.2016.07.008