Christine PoulosArthorn RiewpaiboonJohn F. StewartJohn ClemensSoyeon GuhMagdarina AgtiniDang Duc AnhDong BaiqingZulfiqar BhuttaDipika SurDale WhittingtonRTI InternationalMahidol UniversityThe University of North Carolina at Chapel HillInternational Vaccine Institute, SeoulBadan Penelitian Dan Pengembangan Kesehatan, Kementerian Kesehatan Republik IndonesiaNational Institute of Hygiene and Epidemiology HanoiCenters for Disease Control and PreventionThe Aga Khan UniversityNational Institute of Cholera and Enteric Diseases India2018-05-032018-05-032011-03-01Tropical Medicine and International Health. Vol.16, No.3 (2011), 314-32313653156136022762-s2.0-79951730629https://repository.li.mahidol.ac.th/handle/20.500.14594/12077Objective To generate community-based estimates of the public (paid by the government) and private (paid by households) costs of blood culture-confirmed typhoid fever in Hechi, China; North Jakarta, Indonesia; Kolkata, India; Karachi, Pakistan and Hue, Vietnam. Methods To measure out-of-pocke t costs of illness and lost earnings, families with culture-proven cases were surveyed 7, 14 and 90days after onset of illness. Public costs of treatment were measured at local health facilities using a micro costing (bottom-up) method. Results The costs of hospitalized cases ranged from USD 129 in Kolkata to USD 432 in North Jakarta (hospitalization rates varied from 2% in Kolkata to 40% in Hechi) and the costs of non-hospitalized cases ranged from USD 13 in Kolkata to USD 67 in Hechi. Where costs were highest (Hechi, North Jakarta and Karachi), the bulk of the costs of hospitalized cases was borne by families, comprising up to 15% of annual household income. Conclusion Although these estimates may understate true costs due to the fact that higher quality treatment may have been provided earlier-than-usual, this multi-country community-based study contributes to evidence on the public and private costs of typhoid fever in developing countries. These cost estimates were used in a cost-effectiveness analysis of typhoid vaccines and will help policymakers respond to World Health Organization's updated typhoid fever immunization recommendations. © 2011 Blackwell Publishing Ltd.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1111/j.1365-3156.2010.02711.x