Nongluk SriwilaijaroenMei LiuMei Lin GoPrapon WilairatMahidol UniversityUniversity of2018-08-202018-08-202006-07-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.4 (2006), 607-612012515622-s2.0-33750217087https://repository.li.mahidol.ac.th/handle/123456789/23702Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.Mahidol UniversityMedicineArticleSCOPUS