Thanaporn ChantarodsakunThammasit VongsetskulKulachart JangpatarapongsaPatoomratana TuchindaSukanda UamsiriChuthamas BamrungcharoenSupeecha KumkatePakorn OpaprakasitPramuan TangboriboonratMahidol UniversitySirindhorn International Institute of Technology, Thammasat University2018-11-092018-11-092014-01-01Polymer Bulletin. Vol.71, No.12 (2014), 3163-3176017008392-s2.0-84920082508https://repository.li.mahidol.ac.th/handle/123456789/33667© 2014, Springer-Verlag Berlin Heidelberg. [6]-Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW ~ 3 × 104 g/mol) fibers (375 ± 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that [6]-gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97 % of the loaded [6]-gingerol could be released from the loaded fibers to the acetate buffer solution at 37 °C, whereas only ~74 % of it could be done from the corresponding films. About 92 % of [6]-gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65 %.Mahidol UniversityChemistryMaterials SciencePhysics and AstronomyArticleSCOPUS10.1007/s00289-014-1243-x