Teri A. ManolioCarolyn M. HutterMark AviganRicardo CibottiRobert L. DavisJoshua C. DennyLois La GrenadeLisa M. WheatleyMary N. CarringtonWasun ChantratitaWen Hung ChungAndrea D. DaltonShuen Iu HungMing Ta Michael LeeJ. Steven LeederJuan J.L. LertoraSurakameth MahasirimongkolHoward L. McLeodMaja MockenhauptMichael PacanowskiElizabeth J. PhillipsSimone PinheiroMunir PirmohamedCynthia SungWimon SuwankesawongLauren TrepanierSanta J. TumminiaDavid VeenstraRika YuliwulandariNeil H. ShearLeidos Inc.National Yang-Ming University TaiwanChang Gung Memorial HospitalUniversität Freiburg im BreisgauUniversity of Wisconsin Madison, School of Veterinary MedicineMassachusetts Institute of TechnologyThe Food and Drug Administration, Thailand Ministry of Public HealthUniversity of LiverpoolChang Gung UniversityMurdoch UniversityChildren's Mercy Hospitals and ClinicsNational Institute of Allergy and Infectious DiseasesNational University of SingaporeUniversity of TorontoNIH Clinical CenterFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityThailand Ministry of Public HealthUniversity of Washington, SeattleNational Human Genome Research InstituteFood and Drug AdministrationGeisinger Health SystemNational Eye InstituteNational Institute of Arthritis and Musculoskeletal and Skin DiseasesMoffitt Cancer CenterVanderbilt UniversityUniversity of Tennessee Health Science CenterStevens-Johnson Syndrome FoundationYARSI University2019-08-282019-08-282018-03-01Clinical Pharmacology and Therapeutics. Vol.103, No.3 (2018), 390-39415326535000992362-s2.0-85041800780https://repository.li.mahidol.ac.th/handle/20.500.14594/46933© 2017 American Society for Clinical Pharmacology and Therapeutics Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1002/cpt.890