Jittra SuthiwongJaroon WandeeSiripit PitchuanchomPunchapat SojikulVeerapol KukongviriyapanChavi YenjaiFaculty of Medicine, Khon Kaen UniversityKhon Kaen UniversityMahidol UniversityMahasarakham University2019-08-232019-08-232018-08-01Medicinal Chemistry Research. Vol.27, No.8 (2018), 2042-204915548120105425232-s2.0-85049671953https://repository.li.mahidol.ac.th/handle/20.500.14594/45486© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC 50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC 50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.Mahidol UniversityChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1007/s00044-018-2214-9