Witaya ThamavitMalcolm A. MooreSomsak RuchirawatNobuyuki ItoMahidol UniversityNagoya City University Medical School2018-08-102018-08-101992-02-01Carcinogenesis. Vol.13, No.2 (1992), 309-311014333342-s2.0-0026567040https://repository.li.mahidol.ac.th/handle/20.500.14594/22258The effects of repeated Praziquantel administration, subsequent to infection and reinfection w Opisthorchis viverrini (OV), on lesion development in the Syrian hamster liver were investigated. Five applications of the antihelminthic drag were made (300 mg/kg body wt, i.g.), each time ∼5 weeks after dosing with 60-80 OV metacercarine at weeks 0, 8, 16, 24 and 32. The animals were then maintained until week 40 when they were killed; histopathological investigation revealed no significant development of either hepatocellular of cholangiocellular preneoplastic/neoplastic lesions. The results indicate that repeated exposure to Praziquantel at levels sufficient for successful removal of parasite infestation does not itself carry carcinogenic risk. © 1992 Oxford University Press.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1093/carcin/13.2.309