Nattha IngavatJeffrey DobereinerSuthep WiyakruttaChulabhorn MahidolSomsak RuchirawatPrasat KittakoopCenter for Environmental HealthBrandeis UniversityMahidol UniversityChulabhorn Research InstituteThe Institute of Science and Technology for Research and Development, Mahidol University2018-09-132018-09-132009-11-30Journal of Natural Products. Vol.72, No.11 (2009), 2049-2052016338642-s2.0-73349134679https://repository.li.mahidol.ac.th/handle/123456789/27114A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus. © 2009 American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsNoteSCOPUS10.1021/np9003883