Cholatip WiratkapunPachara PatanajareetBussanee WibulpholprasertPanuwat LertsithichaiMahidol University2018-05-032018-05-032011-10-01Japanese Journal of Radiology. Vol.29, No.8 (2011), 547-5531867108X186710712-s2.0-81855224552https://repository.li.mahidol.ac.th/handle/123456789/12284Purpose. The aim of this study was to estimate the upstaging rate of ductal carcinoma in situ (DCIS) diagnosed by core needle biopsy (CNB) under imaging guidance and to identify factors related to upstaging. Materials and methods. During an 8-year period, pure DCIS was diagnosed by imaging-guided CNB followed by defi nitive surgery in 128 patients. Data on pathological, clinical, and radiological fi ndings were obtained. Results. DCIS upstaging in the present study was 24% (31 of 128 patients had invasive cancer in the fi nal surgical specimen), and the rate was 41% if the cases with microinvasion were included. Factors signifi cantly associated with any type of upstaging included radiological factors (BI-RADS category), factors related to CNB technique (modality of image guidance, size of the core needle, number of cores), and pathological factors (histological grading and presence of comedonecrosis). Multivariable analysis revealed that higher histological grade [odds ratio (OR) and 95% confi dence interval (CI) were 2.50 (1.10-5.67)], smaller needle size (no. 14 vs. no. 11) [OR 3.57 (1.11-11.4)] , and the presence of comedonecrosis [OR 3.78 (1.32-10.8)] were signifi cantly and independently related to upstaging. Conclusion. High-grade DCIS, using a smaller needle, and the presence of comedonecrosis in the CNB specimen were associated with a higher risk for invasive carcinoma. © Japan Radiological Society 2011.Mahidol UniversityMedicineArticleSCOPUS10.1007/s11604-011-0595-5