Penchom PeungvichaYuvadee WongkrajangBoontium KongsaktrakoonKanjana JittipornSomsak Nualkaewเพ็ญโฉม พึ่งวิชายุวดี วงษ์กระจ่างบุญเทียม คงศักดิ์ตระกูลสมศักดิ์ นวลแก้วMahidol University. Faculty of Pharmacy. Department of PhysiologyNaresuan University. Faculty of Allied Health Sciences. Department of Cardio-thoracic TechnologyMahasarakham University. Faculty of Pharmacy. Pharmaceutical Chemistry and Natural Product Research Unit2015-03-282021-06-112015-03-282021-06-1120152014Journal of Asian Association of Schools of Pharmacy. Vol.3, (2014), 299‐305.2286-6493https://repository.li.mahidol.ac.th/handle/20.500.14594/62716Fire Ha Kong recipe in a concentration range of 10-40 µl/ml was used to test in an in vitro uterine contraction inhibition. Contraction frequencies and amplitudes of the normal uterine of estrogen-primed non-pregnant rats were monitored. A decline in the frequencies of uterine contractions of 43.8 - 93.6% was detected. Addition of Fire Ha Kong at the final concentrations of 20-40 ?l/ml inhibited the amplitudes of uterus contraction by 57.1% and 85.7%, respectively. The reductions in area under the curve (AUC) of contractions were 57.1% and 85.7% for the added concentrations. Fire Ha Kong recipe revealed inhibitory effects on the uterine response to oxytocin (10-11 M) 31.9% and 29.3% only in frequency but not in amplitude and AUC in comparison to oxytocin alone. These results indicate that the tocolytic potential of Fire Ha Kong recipe may involve oxytocin receptor-dependent pathway or reduce the intracellular availability of calcium ions.273.32 KBapplication/pdfengMahidol UniversityFire Ha Kong recipeUterine contractionsIn Vitro testRatOxytocinResearch ArticleAsian Association of Schools of Pharmacy