Narumol PhosrithongWeerasak SameePatcharawee NunthanavanitJiraporn UngwitayatornSiam UniversitySrinakharinwirot UniversityMahidol University2018-06-112018-06-112012-06-01Chemical Biology and Drug Design. Vol.79, No.6 (2012), 981-98917470285174702772-s2.0-84860477134https://repository.li.mahidol.ac.th/handle/20.500.14594/13715Forty-eight chromone derivatives were evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, ferrous ions (Fe 2+ ) chelating activity test, total antioxidant activity test (Ferric thiocyanate and Thiobarbituric acid methods), and total reductive capability (potassium ferricyanide reduction). 7,8-Dihydroxy-2-(3′-trifluoromethylphenyl)-3-(3″-trifluoromethylbenzoyl) chromone 32 showed stronger radical scavenging and metal chelating activities than butylated hydroxytoluene, vitamin E, and trolox. Chromone derivatives that exhibited good radical scavenging and metal chelating also displayed strong total antioxidant and reductive power activities. The results obtained from this study indicated that the synthesized chromone derivatives have remarkable antioxidant activity. © 2012 John Wiley & Sons A/S.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1111/j.1747-0285.2012.01368.x