Paomephan P.Hassan K.Kirchenwitz M.Pfütze S.Surup F.Císařová I.Boonchird C.Stadler M.Mahidol University2025-08-142025-08-142025-07-25Journal of Natural Products Vol.88 No.7 (2025) , 1840-1846https://repository.li.mahidol.ac.th/handle/123456789/111610Eight unprecedented terpenoids were isolated from submerged cultures of a polyporoid basidiomycete originating from Thailand (which had been referred to as "Cerrena sp." in a previous publication) by preparative chromatography. Their chemical structures were elucidated by extensive two-dimensional nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry. One of the compounds was crystallized, and its absolute configuration was established by X-ray crystallography. Among the isolated metabolites were several members of the rare nitrogen-containing drimane type and one dimeric drimane, which consists of a nitrogen-containing monomer and a regular monomer. The latter compound represents a hitherto unknown type of terpenoid natural product. The metabolites were subjected to a biological characterization, and some of them showed significant neurotrophic effects. Notably, several of the compounds significantly enhanced the outgrowth of neurites in PC12 cells when treated with 5 ng/mL nerve growth factor. On the other hand, they were devoid of significant cytotoxic and antimicrobial effects.Pharmacology, Toxicology and PharmaceuticsChemistryBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1021/acs.jnatprod.5c006692-s2.0-1050124168971520602540669013