Pimolpan PithayanukulSasitorn LaovachirasuwanRapepol BavovadaNarumol PakmaneeRutt SuttisriMahidol UniversityChulalongkorn UniversityThai Red Cross Agency2018-07-242018-07-242004-01-01Journal of Ethnopharmacology. Vol.90, No.2-3 (2004), 347-352037887412-s2.0-0842326392https://repository.li.mahidol.ac.th/handle/20.500.14594/21814The butanolic and purified butanolic extracts (PBEs) of Eclipta prostrata were evaluated for their anti-venom potential. Inhibition of lethal, hemorrhagic, proteolytic, and phospholipase A2activities of Calloselasma rhodostoma (Malayan pit viper (MPV)) venom by these extracts were determined. Demethylwedelolactone was identified as their major constituent. The butanolic extract, at 2.5mg per mouse, was able to completely neutralize the lethal activity of 2LD50of MPV venom, but increasing the dose diminished the effect. The PBE, at 1.5-4.5mg per mouse, was able to neutralize the lethality of the venom at around 50-58%. Both extracts partially inhibited the hemorrhagic activity but displayed very low anti-phospholipase A2activity and did not inhibit proteolytic activity of MPV venom. © 2003 Elsevier Ireland Ltd. All rights reserved.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.jep.2003.10.014