Rakkreat WikiniyadhaneeTassanee LerksuthiratWasana StitchantrakulSermsiri ChitphukThanyachai SuraDonniphat Dejsuphong2024-03-282024-03-282023-03-162020https://repository.li.mahidol.ac.th/handle/20.500.14594/97772SYNTRAIN CONFERENCE Genomic Instability in Cancer From tumour evolution to novel cures (online event).Organized by the SYNTRAIN Consortuim and the University of Patras, Greece. October 20-22, 2020Tripartite motif-containing protein 29 (TRIM29) is involved in DNA double-strand break (DSB) repair. However, the specific roles of TRIM29 in DNA repair are not clearly understood. To investigate the involvement of TRIM29 in DNA DSB repair, we disrupted TRIM29 in DT40 cells by gene targeting with homologous recombination (HR). Disrupting three alleles of TRIM29 not only decreased the recruitment of 53BP1, but also subsequently increased the recruitment of RAD51 to DNA DSBs in response to DNA DSBs in vertebrate cells.application/pdfengผลงานนี้สงวนสิทธิ์โดยมหาวิทยาลัยมหิดล ห้ามทำซ้ำ คัดลอก หรือนำไปเผยแพร่ตัดต่อโดยมิได้รับอนุญาตเป็นลายลักษณ์อักษรDT40TRIM29DNA damageDNA repairDNA double-strand breaksPoster PresentationSYNTRAIN Consortuim and the University of Patras