Charat ThongprayoonTananchai PetnakWisit KaewputMichael A. MaoBoonphiphop BoonphengTarun BathiniSaraschandra VallabhajosyulaPloypin LertjitbanjongFawad QureshiWisit CheungpasitpornRamathibodi HospitalThe University of ArizonaPhramongkutklao College of MedicineDavid Geffen School of Medicine at UCLAEmory University School of MedicineUniversity of Tennessee Health Science CenterMNFL2022-08-042022-08-042021-08-01Hospital practice (1995). Vol.49, No.3 (2021), 203-208215483312-s2.0-85112131810https://repository.li.mahidol.ac.th/handle/123456789/77993BACKGROUND: This study aimed to 1) determine the incidence of acute kidney injury (AKI), 2) identify risk factors for AKI, and 3) evaluate the impact of AKI on in-hospital outcomes in hospitalized patients for methanol intoxication. METHODS: We searched the National Inpatient Sample Database for hospitalized patients from 2003 to 2014 with a primary diagnosis of methanol intoxication. We excluded patients with end-stage kidney disease. We identified the AKI using a discharge diagnosis code. We compared clinical characteristics, in-hospital treatment, outcomes, and resource use between AKI and non-AKI patients. RESULTS: A total of 603 hospital admissions for methanol intoxication were analyzed. AKI developed in 135 (22.4%) admissions. Anemia (OR 3.43 p < 0.001), hypertension (OR 1.86; p = 0.02), volume depletion (OR 3.46; p = 0.001), sepsis (OR 6.91; p < 0.001), rhabdomyolysis (OR 6.25; p = 0.003), and acute pancreatitis (OR 5.30; p = 0.004) were independent risk factors for AKI development. AKI was significantly associated with increased risk of in-hospital mortality and organ failure. AKI patients needed more mechanical ventilation, and extracorporeal therapy, had longer length of hospital stay, and higher hospitalization costs. CONCLUSION: Over one-fifth of methanol intoxication patients developed AKI during hospitalization. AKI was associated with higher morbidity, mortality, and resource utilization.Mahidol UniversityMedicineArticleSCOPUS10.1080/21548331.2021.1882239