Sawektreeratana N.Krachangchaeng C.Pittayanurak P.Betterley N.M.Chairoungdua A.Wongpan A.Panvongsa W.Janthakit P.Nalaoh P.Promarak V.Nuntasaen N.Reutrakul V.Kuhakarn C.Hongthong S.Mahidol University2023-12-122023-12-122023-11-24Organic letters Vol.25 No.46 (2023) , 8183-8187https://repository.li.mahidol.ac.th/handle/123456789/91432The structures of potent cytotoxic cycloheptapeptides, mallotumides A-C (1-3, respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC50 values ranging from 0.60 to 4.02 nM.ChemistryArticleSCOPUS10.1021/acs.orglett.3c026412-s2.0-851784952041523705237902783