Witaya ThamavitMalcolm A. MooreYoshio HiasaNobuyuki ItoMahidol UniversityUniversity of New South Wales (UNSW) AustraliaNara Medical UniversityNagoya City University Medical School2018-06-142018-06-141988-01-01Japanese Journal of Cancer Research. Vol.79, No.8 (1988), 909-91613497006091050502-s2.0-0023690509https://repository.li.mahidol.ac.th/handle/123456789/15532Combined administration of 0.1% nitrite and 0.1% aminopyrine in the drinking water for eight to ten weeks resulted in subsequent development of both hepatocellular nodules and cholangiofibrotic lesions/cholangiocellular carcinomas in Syrian golden hamsters. Additional prior dosing with Opisthorchis viverrini metacercariae (100/animal) induced inflammatory and proliferative changes in the livers of infected hamsters and was associated with a significant increase in yields of hepatocellular and cholangiocellular preneoplastic and neoplastic lesions. Thus, environmental factors thought to be casually related to the high levels of human liver cancer observed in the Northeastern provinces of Thailand were sufficient to bring about development of equivalent tumors in experimental animals. The results indicate that parasite associated liver injury and non‐specific compensatory regeneration may play an important role in generation of both hepatocellular and cholangiocellular carcinomas in man. Copyright © 1988, Wiley Blackwell. All rights reservedMahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1111/j.1349-7006.1988.tb00054.x