Vichai ReutrakulNatthinee AnantachokeManat PohmakotrThaworn JaipetchChalobon YoosookJittra KasisitChanita NapaswaAmpai PanthongThawatchai SantisukSamran PrabpaiPalangpon KongsaereePatoomratana TuchindaMahidol UniversityChiang Mai UniversityThailand Royal Forest Department2018-09-242018-09-242010-03-12Planta Medica. Vol.76, No.4 (2010), 368-37114390221003209432-s2.0-77749316840https://repository.li.mahidol.ac.th/handle/20.500.14594/28759Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5), were isolated from the leaves and twigs of Garcinia hanburyi. Compounds 13 were also isolated from the resin of this plant. The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (14) displayed anti-HIV1 activities in the anti-HIV1 reverse transcriptase (ICvalues 16.3116.9g/mL) and syncytium assays (EC5.673.6g/mL, SI 1.73.3). Moreover compounds 14 exhibited anti-inflammatory activity in an ethyl phenylpropiolate (EPP)-induced ear edema model. © Georg Thieme Verlag KG Stuttgart New York.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1055/s-0029-1186193