Maneekarn ChinworrungseePrasat KittakoopJanya SaenboonruengPalangpon KongsaereeYodhathai ThebtaranonthMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-08-202018-08-202006-10-01Journal of Natural Products. Vol.69, No.10 (2006), 1404-1410016338642-s2.0-33845460633https://repository.li.mahidol.ac.th/handle/20.500.14594/22860Eight new compounds (2-9), together with a known dithiodiketopiperazine (1), were isolated from the seed fungus Menisporopsis theobromae BCC 3975. The structures of these substances were elucidated by analyses of spectroscopic data. Compounds 1 and 4 exhibited moderate cytotoxicity against BC-1 cell lines with IC50 values of 29.2 and 57.4 μM, respectively. Cytotoxicity of 1, 2, 4, and 9 against the NCI-H187 cell line showed respective IC 50 values of 22.9, 20.3, 1.8, and 56.6 μM. Compounds 2 and 4 exhibited antimalarial activity with IC50 values of 2.95 and 28.8 μM, respectively. Substances 1, 4, 7, 8, and 9 possessed weak antimycobacterial activity (MIC 154.8-952.3 μM), while compounds 2 and 3 showed potent antimycobacterial activity with respective MIC values of 1.24 and 7.14 μM. © 2006 American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityAgricultural and Biological SciencesChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np0601197