Wanitchaya KittikraisakFrits Van GriensvenMichael MartinJanet McNichollPeter B. GilbertRutt ChuachoowongSuphak VanichseniRuengpung SutthentJordan W. TapperoTimothy D. MastroDale J. HuMarc GurwithDwip KitayapornUdomsak SangkumKachit ChoopanyaThailand Ministry of Public HealthNational Center for HIV/AIDS, Viral Hepatitis, STD, and TB PreventionUniversity of Washington, SeattleMahidol UniversityBangkok Vaccine Evaluation GroupVaxGen, Inc.Bangkok Metropolitan AdministrationBumrungrad International HospitalFamily Health International2018-09-132018-09-132009-08-01Journal of Acquired Immune Deficiency Syndromes. Vol.51, No.5 (2009), 601-608152541352-s2.0-68449096170https://repository.li.mahidol.ac.th/handle/20.500.14594/27998BACKGROUND:: We investigated effects of vaccination with AIDSVAX B/E HIV-1 candidate vaccine on blood and seminal plasma HIV-1 RNA viral loads (BVL and SVL, respectively) in vaccine recipients (VRs) and placebo recipients (PRs) who acquired infection. METHODS:: Linear mixed models were fitted for repeated measurements of BVL. Generalized estimating equations were used to assess the difference in SVL detectability between VRs and PRs. RESULTS:: A total of 196 participants became HIV-1 infected during the trial. Thirty-two (16%) became infected with HIV-1 subtype B and 164 (84%) with HIV-1 subtype CRF01-AE. Per protocol-specified analysis, there were no differences in BVL levels between VRs and PRs. When stratified by HIV-1-infecting subtype, vaccination with AIDSVAX B/E was initially associated with higher BVL among HIV-1 CRF01-AE-infected VRs compared with HIV-1 CRF01-AE-infected PRs; however, this difference did not persist over time. HIV-1 subtype B-infected VRs had slightly higher BVL levels and were more likely to have detectable SVL during the follow-up period than HIV-1 subtype B-infected PRs. CONCLUSIONS:: Subtle differences in BVL and SVL were detected between VRs and PRs. These results may help to further understand the dynamics between HIV-1 vaccination, HIV-1-infecting subtypes, and subsequent viral expression in different body compartments. Copyright © 2009 by Lippincott Williams & Wilkins.Mahidol UniversityMedicineArticleSCOPUS10.1097/QAI.0b013e3181a44700