Annemarie E. BrouwerAsna A. SiddiquiMaartje I. KesterKim C.E. SigaloffAdul RajanuwongSaran WannapasniWirongrong ChierakulThomas S. HarrisonSt George's University of LondonMahidol UniversityRadboud University Nijmegen Medical CentreAlkmaar Medical CentreDepartment of Internal MedicineSappasitthiprasong Hospital2018-08-242018-08-242007-03-01Journal of Infection. Vol.54, No.3 (2007)016344532-s2.0-33847053609https://repository.li.mahidol.ac.th/handle/20.500.14594/24979The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-γ, TNF-α, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease. © 2006 The British Infection Society.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.jinf.2006.10.002