Yuki InahashiMasato IwatsukiAki IshiyamaAtsuko MatsumotoTomoyasu HiroseJun OshitaToshiaki SunazukaWatanalai PanbangredYoko TakahashiMarcel KaiserKazuhiko OtoguroSatoshi O'muraKitasato UniversityMahidol UniversitySwiss Tropical and Public Health Institute (Swiss TPH)Universitat Basel2018-11-232018-11-232015-02-20Organic Letters. Vol.17, No.4 (2015), 864-86715237052152370602-s2.0-84923379773https://repository.li.mahidol.ac.th/handle/20.500.14594/35498© 2015 American Chemical Society. Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute stereochemistry, were elucidated by a combination of spectroscopic analyses and a series of chemical derivatization studies. Actinoallolide A showed the most potent and selective in vitro anti-trypanosomal activity without cytotoxicity. A new class of promising lead compounds was identified for the development of drugs for both sleeping sickness and Chagas disease.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1021/ol5037216