Juthathip MongkolsapayaThaneeya DuangchindaWanwisa DejnirattisaiSirijit VasanawathanaPanisadee AvirutnanAroonroong JairungsriNuanpan KhemnuNattaya TangthawornchaikulPojchong ChotiyarnwongKanokwan Sae-JangMichael KochYvonne JonesAndrew McMichaelXiaoning XuPrida MalasitGavin ScreatonHammersmith HospitalMahidol UniversityKhon Kaen Regional HospitalThailand National Center for Genetic Engineering and BiotechnologyWellcome TrustJohn Radcliffe Hospital2018-08-202018-08-202006-03-15Journal of Immunology. Vol.176, No.6 (2006), 3821-3829002217672-s2.0-33644838912https://repository.li.mahidol.ac.th/handle/123456789/23352Dengue virus infection poses a growing public health and economic burden in a number of tropical and subtropical countries. Dengue circulates as a number of quasispecies, which can be divided by serology into four groups or serotypes. An interesting feature of Dengue, recognized over five decades ago, is that most severe cases that show hemorrhagic fever are not suffering from a primary infection. Instead, they are reinfected with a virus of different serotype. This observation poses considerable problems in vaccine design, and it is therefore imperative to gain a full understanding of the mechanisms underlying this immunological enhancement of disease. In this study, we examined a T cell epitope restricted by HLA-A*24, a major MHC class I allele, in Southeast Asia in a cohort of children admitted to a hospital with acute Dengue infection. The cytokine profiles and the degranulation capacity of T cells generated to this epitope are defined and compared across different viral serotypes. Cross-reactive Dengue-specific T cells seem to show suboptimal degranulation but high cytokine production, which may contribute to the development of the vascular leak characteristic of Dengue hemorrhagic fever. Copyright © 2006 by The American Association of Immunologists, Inc.Mahidol UniversityImmunology and MicrobiologyArticleSCOPUS10.4049/jimmunol.176.6.3821