Ekkasit KumarnsitNiwat KeawpradubUraporn VongvatcharanonKitja SawangjaroenPiyarat GovitrapongPrince of Songkla UniversityThe Institute of Science and Technology for Research and Development, Mahidol University2018-06-212018-06-212005-09-01Fitoterapia. Vol.76, No.6 (2005), 534-5390367326X2-s2.0-26944494633https://repository.li.mahidol.ac.th/handle/20.500.14594/17160In the present study, we investigated the effect of the dichloromethane fraction from Areca catechu nut on the severity of naloxone-precipitated morphine withdrawal in morphine-dependent mice. A single intraperitoneal injection of dichloromethane fraction at dose of 125 and 175 mg/kg significantly delayed the onset of withdrawal jumping behavior in a concentration-dependent manner compared to that of saline controls. The dichloromethane fractions also significantly decreased jumping numbers and faecal and urinary excretions during the withdrawal period. © 2005 Elsevier B.V. All rights reserved.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.fitote.2005.04.015