Ashley M. VaughanRichard S. PinapatiIan H. CheesemanNelly CamargoMatthew FishbaugherLisa A. CheckleyShalini NairCarolyn A. HutyraFrançois H. NostenTimothy J.C. AndersonMichael T. FerdigStefan H.I. KappeBiomedical Research InstituteUniversity of Notre DameTexas Biomedical Research InstituteMahidol UniversityUniversity of Washington, Seattle2018-11-232018-11-232015-06-30Nature Methods. Vol.12, No.7 (2015), 631-63315487105154870912-s2.0-84934442316https://repository.li.mahidol.ac.th/handle/123456789/35432© 2015 Nature America, Inc. All rights reserved. Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1038/nmeth.3432