Site-Specific Synthesis of β-Fluorinated γ-Butyrolactams via Decarboxylative Fluorination of β-Carboxyl-γ-Butyrolactams

Supasorn Phae-nokManat PohmakotrChutima KuhakarnVichai ReutrakulDarunee SoorukramMahidol University2020-01-272020-01-272019-01-01European Journal of Organic Chemistry. Vol.2019, No.29 (2019), 4710-4720109906901434193X2-s2.0-85069882375https://repository.li.mahidol.ac.th/handle/20.500.14594/50582© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Monofluorinated cyclic nitrogen-containing compounds are synthetically useful scaffolds in organic synthesis and medicinal applications. In this report, AgNO3 mediated decarboxylative fluorination of β-carboxyl-γ-butyrolactams using Selectfluor® as a fluorine source was described to achieve a site-specific synthesis of β-fluorinated γ-butyrolactams.Mahidol UniversityChemistrySite-Specific Synthesis of β-Fluorinated γ-Butyrolactams via Decarboxylative Fluorination of β-Carboxyl-γ-ButyrolactamsArticleSCOPUS10.1002/ejoc.201900685