Peerut Chienwichaiพีรุทย์ เชียรวิชัยWang NguitragoolJetsumon Prachumsriเจตสุมน ประจำศรีSupachai Topanurakศุภชัย โตภาณุรักษ์Mahidol University. Faculty of Tropical Medicine. Department of Social and Environmental MedicineMahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and GeneticsMahidol University. Faculty of Tropical Medicine. Mahidol Vivax Research Unit2015-06-292021-08-172015-06-292021-08-172015-06-262014https://repository.li.mahidol.ac.th/handle/20.500.14594/63147Joint International Tropical Medicine Meeting 2014: 3D perspectives on tropical medicine: drivers, diversity and determination the 8th seminar on food-and water-borne parasitic zoonoses: 2-4 December 2014: Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2014. p. 224.Apicomplexans lack the ability to synthesize fatty acids de novo because it is different from human fatty acid synthesis. Plasmodium has an essential unique protein on its parasitovacuole membrane (PVM) called UIS3 (upregulated infective sporozoite 3). UIS3 binds to host L-FABP (liver-fatty binding protein) in order to convey essential lipids through PVM. L-FABP plays an important role in lipid synthesis, it has been hypothesized that interaction between UIS3 and L-FABP interfere in the overall fatty acid metabolism of hepatocytes. Quantitative proteomics have been used for analysis of the protein expression level of hepatocytes. Mass spectrometry data were analyzed by Skyline software with MS1 filtering label free technique. It has been found that the protein involving in glycolytic pathway and fatty acid synthesis pathway such as citrate synthase, fatty acid synthase are up-regulated. This will be analyzed in a further study.engMahidol UniversityApicomplexanProteomicProceeding Poster