N. ApiratikulT. PenglongK. SuksenS. SvastiA. ChairoungduaB. YingyongnarongkulRamkhamhaeng UniversityMahidol University2018-10-192018-10-192013-07-01Russian Journal of Bioorganic Chemistry. Vol.39, No.4 (2013), 444-450106816202-s2.0-84880843147https://repository.li.mahidol.ac.th/handle/20.500.14594/31282A new cholesterol-based cationic lipid was synthesized; liposomes prepared on its basis were evaluated as drug delivery vehicles for curcumin. Free and liposome-encapsulated curcumin cytotoxicity against HeLa, A549, HepG2, K562 and 1301 cell lines was assessed. Liposomal curcumin with ED50values ranging from 2.5-10 μM exhibited 2-8 times higher cytotoxicity than free curcumin. The synthetic cholesterol-based cationic lipid also enhanced cellular uptake of curcumin into tested cells. Cationic liposome alone showed low cytotoxicity at high doses with ED50values of 90-210 μM. © 2013 Pleiades Publishing, Ltd.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryConference PaperSCOPUS10.1134/S1068162013030035