Vip ViprakasitSupachai EkwattanakitFaculty of Medicine, Siriraj Hospital, Mahidol University2019-08-282019-08-282018-04-01Hematology/Oncology Clinics of North America. Vol.32, No.2 (2018), 193-21115581977088985882-s2.0-85042103908https://repository.li.mahidol.ac.th/handle/20.500.14594/46776© 2017 Elsevier Inc. At present, thalassemia diseases are classified into transfusion-dependent thalassemia and non–transfusion-dependent thalassemia. This classification is based on the clinical severity of patients determining whether they do require regular blood transfusions to survive (transfusion-dependent thalassemia) or not (non–transfusion-dependent thalassemia). In addition to the previous terminology of “thalassemia major” or “thalassemia intermedia,” this classification has embraced all other forms of thalassemia syndromes such as α-thalassemia, hemoglobin E/β-thalassemia and combined α- and β-thalassemias. Definitive diagnosis of thalassemia and hemoglobinopathies requires a comprehensive workup from complete blood count, hemoglobin analysis, and molecular studies to identify mutations of globin genes.Mahidol UniversityMedicineReviewSCOPUS10.1016/j.hoc.2017.11.006