Si Young LeeHiroshi KinoshitaFumio IharaYasuhiro IgarashiTakuya NihiraOsaka UniversityInstitute of Fruit Tree and Tea Science, NAROToyama Prefectural UniversityMahidol University2018-07-122018-07-122008-05-01Journal of Bioscience and Bioengineering. Vol.105, No.5 (2008), 476-480138917232-s2.0-44949164623https://repository.li.mahidol.ac.th/handle/20.500.14594/18931Entomopathogenic fungi are unique owing to their versatile ability to produce many bioactive compounds and from the dependence of their morphological differentiation on the presence of insect-derived materials. An entomopathogenic fungus, Metarhizium anisopliae HF293, was found to show insect-material-dependent production of antibacterial compounds, which were purified to homogeneity from 10-d culture broth when the production reached maximum. Two compounds were isolated: the major compound was determined to be helvolic acid and the minor one was a novel derivative of helvolic acid (1,2-dihydrohelvolic acid). Discovery of a novel bioactive compound indicated that insect-derived material would be a useful factor for enhancing the diversity of compounds produced by entomopathogenic fungi. © 2008 The Society for Biotechnology, Japan.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemical EngineeringArticleSCOPUS10.1263/jbb.105.476