Kanokwan KulprachakarnNittaya ChansiwKanjana PangjitChada PhisalaphongSuthat FucharoenRobert C. HiderSineenart SantitherakulSomdet SrichairatanakoolChiang Mai UniversityUbon Rajathanee UniversityThailand Ministry of Public HealthMahidol UniversityKing's College London2018-11-092018-11-092014-01-01Asian Pacific Journal of Tropical Biomedicine. Vol.4, No.8 (2014), 663-668222116912-s2.0-84922669147https://repository.li.mahidol.ac.th/handle/123456789/33410© 2014 by the Asian Pacific Journal of Tropical Biomedicine. Objective: To evaluate the iron-chelating properties and free-radical scavenging activities of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) treatment in chronic iron-loaded β-thalassemic (BKO) mice. Methods: The BKO mice were fed with a ferrocene-rich diet and were orally administered with CM1 [50 mg/(kg.day)] for 6 months. Blood levels of non-transferrin bound iron, labile plasma iron, ferritin (Ft) and malondialdehyde were determined. Results: The BKO mice were fed with an iron diet for 8 months which resulted in iron overload. Interestingly, the mice showed a decrease in the non-transferrin bound iron, labile plasma iron and malondialdehyde levels, but not the Ft levels after continuous CM1 treatment. Conclusions: CM1 could be an effective oral iron chelator that can reduce iron overload and lipid peroxidation in chronic iron overload β-thalassemic mice.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.12980/APJTB.4.2014APJTB-2014-0155