Paul N. NewtonWirongrong ChierakulRonatrai RuangveerayuthKamolrat SilamutPramote TeerapongSrivicha KrudsoodSornchai LooareesuwanNicholas J. WhiteMahidol UniversityJohn Radcliffe HospitalMae Sot General Hospital2018-09-072018-09-072001-01-01Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.95, No.5 (2001), 519-523003592032-s2.0-0035467587https://repository.li.mahidol.ac.th/handle/123456789/26591In some areas clinicians have combined parenteral artesunate and quinine in the belief that the 2 drugs would be additive or synergistic in severe malaria. A randomized comparison of the effectiveness of intravenous (iv) artesunate versus iv artesunate and iv quinine together on parasite clearance was conducted in 1998/99 amongst 69 patients with uncomplicated and severe Plasmodium falciparum malaria in western Thailand. The parasite clearance time did not differ significantly between the 2 treatment groups (P = 0.12), but adverse events were significantly more frequent in the artesunate plus quinine group (P = 0.05). Quinine did not have a significant antipyretic effect and artesunate did not affect the electrocardiographic QTc interval. There is no benefit evident from combining parenteral administration of these 2 antimalarial drugs in the acute phase of treatment. © 2002 OUP.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1016/S0035-9203(01)90025-2