Yuda TuranaJeslyn TengkawanYook Chin ChiaBoon Wee TeoJinho ShinGuru Prasad SogunuruArieska Ann SoenartaHuynh Van MinhPeera BuranakitjaroenChen Huan ChenJennifer NailesSatoshi HoshideSungha ParkSaulat SiddiqueJorge SisonApichard SukonthasarnJam Chin TayTzung Dau WangNarsingh VermaYu Qing ZhangJi Guang WangKazuomi KarioDe La Salle Health Sciences InstituteSunway UniversityNational University Health SystemHanyang University Medical CenterJichi Medical UniversityYonsei University Health SystemShanghai Jiao Tong University School of MedicineMadras Institute of Orthopaedics and Traumatology HospitalsKathmandu UniversityUniversity of the East Ramon Magsaysay Memorial Medical CenterHue UniversityFatima Memorial HospitalUniversitas Katolik Indonesia Atma JayaUniversitas IndonesiaUniversity of MalayaFuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeYong Loo Lin School of MedicineNational Taiwan University College of MedicineKing George's Medical UniversityFaculty of Medicine, Siriraj Hospital, Mahidol UniversityNational Yang-Ming University, School of MedicineTan Tock Seng HospitalChiang Mai University2020-05-052020-05-052020-03-01Journal of Clinical Hypertension. Vol.22, No.3 (2020), 415-42217517176152461752-s2.0-85076377016https://repository.li.mahidol.ac.th/handle/123456789/54624© 2019 Wiley Periodicals, Inc. Hypertension is an important public health concern. The prevalence keeps increasing, and it is a risk factor for several adverse health outcomes including a decline in cognitive function. Recent data also show that the prevalence of hypertension and age-related dementia is rising in Asian countries, including in the oldest old group. This study aims to discuss possible treatments for high blood pressure in the elderly and propose an optimal target for BP relative to cognitive outcomes. This review discusses several studies on related blood pressure treatments that remain controversial and the consequences if the treatment target is too low or aggressive. Longitudinal, cross-sectional, and RCT studies were included in this review. An optimum systolic blood pressure of 120-130 mm Hg is recommended, especially in nondiabetic hypertensive patients with significant risk factors. In the oldest old group of patients, hypertension might have a protective effect. The use of calcium channel blockers (CCB) and angiotensin receptor blocker (ARB) is independently associated with a decreased risk of dementia in older people. However, personalized care for patients with hypertension, especially for patients who are frail or very old, is encouraged.Mahidol UniversityMedicineReviewSCOPUS10.1111/jch.13752