Somnuek SungkanuparphMahidol University2018-09-242018-09-242010-04-01Expert Review of Anti-Infective Therapy. Vol.8, No.4 (2010), 371-37317448336147872102-s2.0-77950793606https://repository.li.mahidol.ac.th/handle/123456789/29245In clinical practice, a significant proportion of HIV-infected patients still experience treatment failure during antiretroviral therapy (ART). There is limited information regarding the second treatment failure and its mortality rate. This article assessed the findings of a recently published paper describing analyzed data from the North American AIDS Cohort Collaboration on Research and Design. A total of 7159 out of 36,188 patients who received ART had a second virologic failure from ART. Although the risk of second failure decreased from 1996 to 2005 owing to the evolution of ART, the cumulative mortality at 5 years after onset of second failure was 26%. Strategies to prevent treatment failure are urgently needed in order to minimize the mortality among HIV-infected patients receiving ART. © 2010 Expert Reviews Ltd.Mahidol UniversityImmunology and MicrobiologyMedicineNoteSCOPUS10.1586/eri.10.18