Amornrat JearnpipatkulBhinyo PanijpanMahidol University2018-04-302018-04-301980-01-01Chemico-Biological Interactions. Vol.33, No.1 (1980), 83-90000927972-s2.0-0019160740https://repository.li.mahidol.ac.th/handle/123456789/11190Chloroquine, quinine, mefloquine and quinacrine have been found by difference spectroscopy to interact with hemozoin from Plasmodium berghei, trypsin and pronase-digested methemoglobin, hemin, heme, protoporphyrin IX and hematoporphyrin. These drugs also compete with one another in their binding to hemin. It is proposed that the iron-porphyrin moiety of digested hemoglobin is a common binding site for the accumulation of the schizontocidal drugs in the autophagosomes of the malarial parasite. © 1980.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/0009-2797(80)90045-9