Boonchai P.Kositamongkol C.Jitrukthai S.Phothirat S.Mepramoon E.Nimitpunya P.Srivanichakorn W.Chaisathaphol T.Washirasaksiri C.Auesomwang C.Sitasuwan T.Tinmanee R.Sayabovorn N.Charatcharoenwitthaya P.Phisalprapa P.Mahidol University2023-06-202023-06-202022-05-01Journal of Clinical Medicine Vol.11 No.9 (2022)https://repository.li.mahidol.ac.th/handle/123456789/87320This study investigated differences in the clinical data and prevalence of lean and non-lean patients with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS). Data on patients with MetS who had results of ultrasonography or transient elastography were collected from a Thai university hospital database. Patients with exclusion criteria for NAFLD diagnosis were excluded. Patients’ clinical characteristic and the performances of three non-invasive scoring systems (fatty liver index [FLI], fibrosis-4 [FIB-4] index, and NAFLD fibrosis score [NFS]) were evalu-ated. The 743 subjects were classified into two groups: lean MetS (131 patients) and non-lean MetS (612 patients). The NAFLD prevalence in the non-lean group (62.6%) was higher than that in the lean group (31.3%). The age-adjusted odds ratio was 3.43. Advanced fibrosis was detected in 7.6% of lean patients and 10.8% of non-lean patients. FLI was not sensitive enough to detect NAFLD in the lean group at a high cutoff, but it performed acceptably at a low cutoff. FIB-4 performed better than NFS in determining advanced fibrosis. NAFLD was more common in non-lean than lean pa-tients. Lean patients with MetS had a relatively higher risk of NAFLD than the general population. FLI and FIB-4 index performed acceptably in both groups.MedicineArticleSCOPUS10.3390/jcm110924452-s2.0-8512873779320770383