The aspergillus fumigatus p-type golgi apparatus Ca2+/Mn2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis

Nadthanan PinchaiPraveen Rao JuvvadiJarrod R. FortwendelB. Zachary PerfectLuise E. RoggYohannes G. AsfawWilliam J. SteinbachDuke University School of MedicineMahidol University2018-09-242018-09-242010-03-01Eukaryotic Cell. Vol.9, No.3 (2010), 472-476153597782-s2.0-77649288776https://repository.li.mahidol.ac.th/handle/123456789/28774The Aspergillus fumigatus δpmrA (Golgi apparatus Ca2+/Mn2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased β-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity. © 2010, American Society for Microbiology. All Rights Reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyThe aspergillus fumigatus p-type golgi apparatus Ca2+/Mn2+ ATPase pmra is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesisNoteSCOPUS10.1128/EC.00378-09