Synthesis of aryl α-keto esters via the rearrangement of aryl cyanohydrin carbonate esters

Nopporn ThasanaVilailak PrachyawarakornSopchok TontoolarugSomsak RuchirawatChulabhorn Research InstituteMahidol University2018-07-242018-07-242003-01-27Tetrahedron Letters. Vol.44, No.5 (2003), 1019-1021004040392-s2.0-0037467813https://repository.li.mahidol.ac.th/handle/123456789/20770A facile synthesis of aryl α-keto esters is reported involving the rearrangement of aryl cyanohydrin carbonate esters induced by the α-carbanion to the nitrile group generated by LDA. However, under similar conditions, an o-benzyloxycyanohydrin carbonate ester rearranged via a domino reaction leading to 2-phenylbenzofuran-3-carboxylic acid. © 2003 Elsevier Science Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsSynthesis of aryl α-keto esters via the rearrangement of aryl cyanohydrin carbonate estersArticleSCOPUS10.1016/S0040-4039(02)02725-9