Santikorn ChaimaneeManat PohmakotrChutima KuhakarnVichai ReutrakulDarunee SoorukramMahidol University2018-12-212019-03-142018-12-212019-03-142017-01-01Organic and Biomolecular Chemistry. Vol.15, No.18 (2017), 3985-3994147705202-s2.0-85021655664https://repository.li.mahidol.ac.th/handle/123456789/42053© 2017 The Royal Society of Chemistry. The first asymmetric synthesis of ent-fragransin C1was reported. The key step involves an intramolecular C-O bond formation (furan ring formation) via chemoselective generation of the benzylic carbocation leading to the 2,3-anti-3,4-syn-4,5-anti-tetrahydrofuran moiety as a single diastereomer in good yield. Our synthesis confirms that ent-fragransin C1possesses 2R,3R,4S,5S configurations.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1039/c7ob00749c