Kesinee ChotivanichRachanee UdomsangpetchJulie A. SimpsonPaul NewtonSasithon PukrittayakameeSornchai LooareesuwanNicholas J. WhiteMahidol UniversityJohn Radcliffe Hospital2018-09-072018-09-072000-04-19Journal of Infectious Diseases. Vol.181, No.3 (2000), 1206-1209002218992-s2.0-0034074265https://repository.li.mahidol.ac.th/handle/123456789/26256The multiplication rates and invasiveness of Plasmodium falciparum parasites isolated from adult Thai patients hospitalized with uncomplicated malaria (n = 34) were compared with those from persons with severe malaria (n = 42). To simulate severe malaria and control for host effects, the in vitro cultures were adjusted to 1% parasitemia and used the same red blood cell donor. E falciparum isolates from persons with severe malaria had initial cycle multiplication rates in vitro that were 3-fold higher than those from uncomplicated malaria (median [95% confidence interval], 8.3 [7.1-10.5] vs. 2.8 [1.7-3.9]; P = .001). Parasites causing severe malaria exhibited unrestricted red blood cell invasion, whereas those from uncomplicated malaria were restricted to a geometric mean of 40 (31%-53%) of red blood cells. E falciparum parasites causing severe malaria were less selective and multiplied more at high parasitemias than those causing uncomplicated malaria.Mahidol UniversityMedicineArticleSCOPUS10.1086/315353