Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors

Jun Ichi SakamotoTetsuo KoyamaDaisei MiyamotoSangchai YingsakmongkonKazuya I.P.J. HidariWipawee JampangernTakashi SuzukiYasuo SuzukiYasuaki EsumiKen HatanoDaiyo TerunumaKoji MatsuokaSaitama UniversityUniversity of ShizuokaJapan Science and Technology AgencyKasetsart UniversityMahidol UniversityChubu UniversityRIKEN (The Institute of Physical and Chemical Research)2018-08-242018-08-242007-02-01Bioorganic and Medicinal Chemistry Letters. Vol.17, No.3 (2007), 717-7210960894X2-s2.0-33846323253https://repository.li.mahidol.ac.th/handle/123456789/24256An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with α-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases. © 2006 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsThiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitorsArticleSCOPUS10.1016/j.bmcl.2006.10.085