Nicholas J. WhiteSornchai LooareesuwanRodney E. PhillipsDavid A. WarrellPornthep ChanthavanichPraneet PongpaewMahidol UniversityNuffield Department of Clinical MedicineLiverpool School of Tropical Medicine2018-10-122018-10-121985-04-06The Lancet. Vol.325, No.8432 (1985), 776-778014067362-s2.0-0021955002https://repository.li.mahidol.ac.th/handle/123456789/30870Cerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. They were significantly higher in patients who died (9·0±5·3 mmol/l, mean±SD) than in survivors (3·4±1·1 mmol/l, p=0·0002) and had returned to normal values in each of 9 patients studied after recovery of consciousness. There was a significant negative correlation between CSF lactate and CSF glucose. All 11 patients with CSF lactate concentrations above 6 mmol/l died. CSF lactate is thus an important prognostic indicator in cerebral malaria and these findings suggest that hypoxia contributes to the pathogenesis of this disorder. © 1985.Mahidol UniversityMedicineArticleSCOPUS10.1016/S0140-6736(85)91445-X