Werasak SutipornpalangkulSupeenun UnchenYupin SanvarindaUdom ChantharaksriMahidol UniversityFaculty of Medicine, Siriraj Hospital, Mahidol University2018-09-132018-09-132009-02-01Journal of the Medical Association of Thailand. Vol.92, No.2 (2009), 229-23501252208012522082-s2.0-61449241739https://repository.li.mahidol.ac.th/handle/20.500.14594/28197Background: It is believed that the oxidatively modified lipoproteins play a critical role in activating platelets and is a contributing factor in the etiology of a number of cardiovascular-related diseases. Objective: Identify the active component(s) of oxidized LDL that initiated shape change in plasma-free human platelets prepared by a gel filtration method. Material and Method: Shape change parameter of platelets was monitored following exposure platelets to LDL, copper sulfate-oxidized LDL, and different types of lipids extracted of the corresponding LDL. Results: Oxidized LDL, but not native LDL, increased the shape-change parameter in a concentration-dependent manner. Specifically, phosphatidyl serine from oxidized LDL was responsible for this effect. Conclusion: Oxidized phospholipids generated during the oxidative modification of LDL are likely to be the active components responsible for changes in platelet function.Mahidol UniversityMedicineArticleSCOPUS