Patoomratana TuchindaJinda UdchachonVichai ReutrakulThawatchai SantisukWalter C. TaylorNorman R. FarnsworthJohn M. PezzutoA. Douglas KinghornMahidol UniversityThailand Royal Forest DepartmentThe University of SydneyUniversity of Illinois at Chicago2018-08-102018-08-101991-01-01Phytochemistry. Vol.30, No.8 (1991), 2685-2689003194222-s2.0-0000108005https://repository.li.mahidol.ac.th/handle/20.500.14594/21978From leaves and branches of Melodorum fruticosum, five butenolides have been isolated: (4Z)-6-acetoxy-7-benzoyloxy-2,4-heptadien-4-olide, (4E)-6-acetoxy-7-benzoyloxy-2,4-heptadien-4-olide, (4Z)-7-benzoyloxy-6-hydroxy-2,4-heptadien-4-olide, (4E)-7-benzoyloxy-6-hydroxy-2,4-heptadien-4-olide and (4Z)-6-benzoyloxy-7-hydroxy-2,4-heptadien-4-olide. In addition, two known flavonoids (chrysin, pinocembrin) and benzoic acid were isolated. All butenolides showed cytotoxic activities in several tumour cell lines. The structures of the isolated compounds were elucidated by spectroscopic methods. © 1991.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/0031-9422(91)85123-H