Chanpen KaruwanThitirat MantimPatcharin ChaisuwanPrapin WilairatKate GrudpanPiyada JittangprasertYasuaki EinagaOrawon ChailapakulLeena SuntornsukOraphan AnurukvorakunDuangjai NacaprichaMahidol UniversityChiang Mai UniversitySrinakharinwirot UniversityKeio UniversityChulalongkorn University2018-08-202018-08-202006-01-01Sensors. Vol.6, No.12 (2006), 1837-185014248220142432102-s2.0-33947367459https://repository.li.mahidol.ac.th/handle/123456789/23116This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method. © 2006 by MDPI.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryEngineeringPhysics and AstronomyArticleSCOPUS10.3390/s6121837