Pattama PittayakhajonwutRapheephat SuvannakadSurang ThienhirunSamran PrabpaiPalangpon KongsaereeMorakot TanticharoenThailand National Center for Genetic Engineering and BiotechnologyThailand Royal Forest DepartmentMahidol University2018-06-212018-06-212005-02-21Tetrahedron Letters. Vol.46, No.8 (2005), 1341-1344004040392-s2.0-13244268386https://repository.li.mahidol.ac.th/handle/123456789/16373A structurally unique polyketide, mellisol (1) and 1,8-dihydroxynaphthol 1-O-α-glucopyranoside (3), were isolated from the fungus Xylaria mellisii (BCC 1005). The relative stereostructure of 1 was determined on the basis of X-ray crystallographic data. Compounds 1 and 3 exhibited activity against herpes simplex virus-type 1 with IC50values of 10.50 and 8.40 μg/mL, respectively. They also showed cytotoxic activity against vero cells at the concentration of 40-50 μg/mL. © 2004 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tetlet.2004.12.110