Identification of a novel HIV type 1 CRF01_AE cytotoxic T lymphocyte (CTL) epitope restricted by an HLA-Cw0602 allele and a novel HLA-A0206/peptide restriction

Wannee KantakamalakulMark De SouzaSasitorn BejrachandraSilawun AmpolJosephine CoxRuengpung SutthentMahidol UniversityArmed Forces Research Institute of Medical Sciences, ThailandU.S. Military HIV Research Program2018-08-202018-08-202006-12-01AIDS Research and Human Retroviruses. Vol.22, No.12 (2006), 1271-1282088922292-s2.0-33846191162https://repository.li.mahidol.ac.th/handle/20.500.14594/23278This report describes specific T cell responses to HIV-1 CRF01_AE Env and A Gag peptides in 20 HIV-1 CRF01_AE-infected Thai individuals using an interferon-γ (IFN-γ) enzyme-linked immunospot (ELISpot) assay. Twenty-six potentially novel HLA class I-restricted CD8+ T cell epitopes were identified in 14/20 subjects. Fine mapping analysis using the chromium release cytotoxic T lymphocyte (CTL) assay revealed a novel HLA-Cw0602 restricted epitope of HIV-1 CRF01_AE Env (NAKTIIVHL) and a previously identified HIV-1 A Gag epitope (ATLEEMMTA) with a novel HLA-A0206 restriction. © Mary Ann Liebert, Inc.Mahidol UniversityImmunology and MicrobiologyMedicineIdentification of a novel HIV type 1 CRF01_AE cytotoxic T lymphocyte (CTL) epitope restricted by an HLA-Cw0602 allele and a novel HLA-A0206/peptide restrictionArticleSCOPUS10.1089/aid.2006.22.1271