Sakda Arj-Ong VallibhakaraAmmarin ThakkinstianKunlawat ThadaniponTiwari, Sagar, 1989-2024-01-102024-01-10202020202024Thesis (M.Sc. (Medical Epidemiology))--Mahidol University, 2015https://repository.li.mahidol.ac.th/handle/123456789/92109Medical Epidemiology (Mahidol University 2020)Several studies have suggested that neck circumference (NC) can be used as screening measures for diagnosing obesity-related metabolic complications and might be associated with type 2 diabetes mellitus (T2D) and hypertension (HT) but their results are conflicting. Therefore, we conducted this systematic review and meta-analysis to assess the overall association of NC with T2D and HT in adults. Studies were identified from MEDLINE and Scopus database up to December 2019. The exposure of measurement, i.e., NC could be categorical (high vs low) and continuous data. Clinical outcomes for T2D and HT could be dichotomous data or continuous values, e.g., fasting blood sugar (FBS), glycated hemoglobin (HBA1c), systolic blood pressure (SBP), and diastolic blood pressure (DBP). We included observational studies conducted in adult reporting odds ratio (OR) along with 95% confidence interval (CI) for risk of T2D or HT and correlation coefficient of NC with FBS, HBA1c, SBP, and DBP. Meta-analysis was performed to pool the effects sizes across studies using a random-effect model if heterogeneity was present; otherwise, a fixed-effect model was used. Heterogeneity was assessed by Q test and I2. All studies were assessed with their quality and publication bias. Seventy-three studies with the mean age of 48.5 years were included. Our results indicated high NC have 1.95 (1.31, 2.89) and 2.08 (1.23, 3.52) times higher odds of T2D than low NC among females and males, respectively. For, HT the pooled ORs (95% CI) were 1.88 (1.36, 2.58) and 1.63 (1.26, 2.11) for females and males, respectively. Each 1 cm rising in NC would increase the odds of having T2D and HT in both genders by almost 1.2 and 1.1 respectively. In addition, the unstandardized mean difference of NC was about 1.3 cm higher in T2D and HT than non-T2D and non-HT. Furthermore, we found a positive correlation of NC with FBS, HBA1c, SBP, and DBP in both genders. Finding should be upraised with caution due to high heterogeneity even after subgroup analysis in some cases. More future prospective cohort studies will need to prove and simplify the association.xvi, 199 leaves : ill.application/pdfengผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้าDiabetesHypertensionMaster ThesisMahidol University